A prerequisite for the development of hyperglycaemia in diabetes is when the b cells are unable to secrete sufficient insulin to maintain glucose homeostasis. Current efforts to enhance β-cell function focus mostly on the pathways that stimulate insulin release, but very little is known about the intracellular inhibitory mechanisms that terminate insulin secretion. Salt-inducible kinase 3 (SIK3) is a serine/threonine protein kinase that regulates multiple signalling pathways involved in metabolic regulation in response to changes in hormonal and nutrient status. SIK3 is highly expressed in mouse pancreatic β cells and is highly conserved in humans. However, the role of SIK3 in regulating insulin secretion and b-cell biology has never been studied. In this presentation, I will provide a detailed overview of the physiological roles of salt-inducible kinases in glycaemic control and disease development, with a focus on the regulation of pancreatic beta-cell biology and glucose metabolism by SIK3.