Reuben Shaw
Reuben Shaw is a full professor in the Molecular and Cellular Biology Laboratory at the Salk Institute. Dr. Shaw’s lab focuses on the AMPK signaling pathway, which coordinates metabolism and growth at the cellular and organismal levels across eukaryotes. This pathway is altered in a number of human cancers and altered in metabolic diseases as well. Starting as an Assistant Professor at the Salk Institute in 2006, Dr. Shaw’s lab has been using a combination of biochemistry, cell biology, and genetically engineered mouse models of cancer to dissect the role of the LKB1 – AMPK tumor suppressor pathway in coordinating metabolism, autophagy, and cell growth. This work has led to the identification of several new direct substrates of AMPK which help to provide a molecular framework for how cells reprogram their metabolism and growth under conditions of low nutrients and in response to mitochondrial insults. Dr. Shaw’s lab also utilizes genetic engineered mouse models to explore the roles that reprogramming of glucose and lipid metabolism contributes to tumorigenesis, and to develop and test novel therapeutic approaches for multiple cancer types. In 2016, he was named the Director of the Salk NCI-Designated Cancer Center.
Abstracts this author is presenting: